Edward Chang, MD

Professor
Neurological Surgery
+1 415 502-7346

Dr. Edward Chang is a neurosurgeon who treats patients with epilepsy, brain tumors, and cranial nerve nerve compression syndromes such as trigeminal neuralgia and hemifacial spasm. He is Chairman of the Department of Neurological Surgery at UCSF.

Dr Chang specializes in advanced brain mapping methods to preserve crucial areas for speech and motor functions in the brain. He also has extensive experience with implantable devices that stimulate specific nerves to relieve seizure, movement, pain and other disorders.

Dr Chang's research focuses on the brain mechanisms for speech, movement and human emotion. He co-directs the Center for Neural Engineering and Prostheses, a collaborative enterprise of UCSF and the University of California, Berkeley. The center brings together experts in engineering, neurology and neurosurgery to develop state-of-the-art biomedical technology to restore function for patients with neurological disabilities such as paralysis and speech disorders.

Dr Chang earned his medical degree at UCSF, where he also completed a residency in neurosurgery. He was honored with the Blavatnik National Laureate for Life Sciences in 2015, in recognition of his contributions to deciphering the neural code of speech. Dr. Chang is the inaugural Bowes Biomedical Investigator at UCSF and HHMI Faculty Scholar. Dr Chang was inducted to the National Academy of Medicine in 2020.

Publications: 

Anatomical and behavioural correlates of auditory perception in developmental dyslexia.

Brain : a journal of neurology

Qi T, Mandelli ML, Pereira CLW, Wellman E, Bogley R, Licata AE, Miller Z, Tee BL, de Leon J, Chang EF, Oganian Y, Gorno-Tempini ML

Brain-Computer Interfaces for Restoring Communication.

The New England journal of medicine

Chang EF

Anatomical and behavioral correlates of auditory perception in developmental dyslexia.

bioRxiv : the preprint server for biology

Qi T, Mandelli ML, Watson Pereira CL, Wellman E, Bogley R, Licata AE, Chang EF, Oganian Y, Gorno-Tempini ML

Surgical outcomes following resection in patients with language dominant posterior quadrant epilepsy.

Epilepsy & behavior reports

Saggi S, Garcia JH, Behzadi F, Mallela AN, Garcia PA, Chang EF, Knowlton RC

Hippocampal network activity forecasts epileptic seizures.

Nature medicine

Khambhati AN, Chang EF, Baud MO, Rao VR

Author Correction: A high-performance neuroprosthesis for speech decoding and avatar control.

Nature

Metzger SL, Littlejohn KT, Silva AB, Moses DA, Seaton MP, Wang R, Dougherty ME, Liu JR, Wu P, Berger MA, Zhuravleva I, Tu-Chan A, Ganguly K, Anumanchipalli GK, Chang EF

Large-scale neurophysiology and single-cell profiling in human neuroscience.

Nature

Lee AT, Chang EF, Paredes MF, Nowakowski TJ

A bilingual speech neuroprosthesis driven by cortical articulatory representations shared between languages.

Nature biomedical engineering

Silva AB, Liu JR, Metzger SL, Bhaya-Grossman I, Dougherty ME, Seaton MP, Littlejohn KT, Tu-Chan A, Ganguly K, Moses DA, Chang EF

The speech neuroprosthesis.

Nature reviews. Neuroscience

Silva AB, Littlejohn KT, Liu JR, Moses DA, Chang EF

Stereoelectroencephalography Electrode Implantation for Inpatient Workup of Treatment-Resistant Depression.

Neurosurgery

Starkweather CK, Sugrue LP, Cajigas I, Speidel B, Krystal AD, Scangos K, Chang EF

Development and validation of a nonverbal consensus-based semantic memory paradigm in patients with epilepsy.

Journal of the International Neuropsychological Society : JINS

Tran EB, Vonk JMJ, Casaletto K, Zhang D, Christin R, Marathe S, Gorno-Tempini ML, Chang EF, Kleen JK

Quantitative assessment of preanalytic variables on clinical evaluation of PI3/AKT/mTOR signaling activity in diffuse glioma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Beccari S, Mohamed E, Voong V, Hilz S, Lafontaine M, Shai A, Lim Y, Martinez J, Switzman B, Yu RL, Lupo JM, Chang EF, Hervey-Jumper SL, Berger MS, Costello JF, Phillips JJ

Parallel Encoding of Speech in Human Frontal and Temporal Lobes.

bioRxiv : the preprint server for biology

Hullett PW, Leonard MK, Gorno-Tempini ML, Mandelli ML, Chang EF

Microvascular decompression of a vertebral artery loop causing cervical radiculopathy: illustrative case.

Journal of neurosurgery. Case lessons

Semonche A, Rinaldo L, Lee Y, Dubnicoff T, Matles H, Chou D, Abla A, Chang EF

Encoding of melody in the human auditory cortex.

Science advances

Sankaran N, Leonard MK, Theunissen F, Chang EF

Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy.

Science advances

Zhu D, Brookes DH, Busia A, Carneiro A, Fannjiang C, Popova G, Shin D, Donohue KC, Lin LF, Miller ZM, Williams ER, Chang EF, Nowakowski TJ, Listgarten J, Schaffer DV

Anatomical registration of intracranial electrodes. Robust model-based localization and deformable smooth brain-shift compensation methods.

Journal of neuroscience methods

Blenkmann AO, Leske SL, Llorens A, Lin JJ, Chang E, Brunner P, Schalk G, Ivanovic J, Larsson PG, Knight RT, Endestad T, Solbakk AK

Intraoperative cortical stimulation mapping with laryngeal electromyography for the localization of human laryngeal motor cortex.

Journal of neurosurgery

Ammanuel SG, Kondapavulur S, Lu AY, Breshears JD, Clark JP, Silva AB, Chang EF

Large-scale single-neuron speech sound encoding across the depth of human cortex.

Nature

Leonard MK, Gwilliams L, Sellers KK, Chung JE, Xu D, Mischler G, Mesgarani N, Welkenhuysen M, Dutta B, Chang EF

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.

Acta neuropathologica

Hadad S, Gupta R, Oberheim Bush NA, Taylor JW, Villanueva-Meyer JE, Young JS, Wu J, Ravindranathan A, Zhang Y, Warrier G, McCoy L, Shai A, Pekmezci M, Perry A, Bollen AW, Phillips JJ, Braunstein SE, Raleigh DR, Theodosopoulos P, Aghi MK, Chang EF, Hervey-Jumper SL, Costello JF, de Groot J, Butowski NA, Clarke JL, Chang SM, Berger MS, Molinaro AM, Solomon DA

Dissecting neural computations in the human auditory pathway using deep neural networks for speech.

Nature neuroscience

Li Y, Anumanchipalli GK, Mohamed A, Chen P, Carney LH, Lu J, Wu J, Chang EF

Neural control of lexical tone production in human laryngeal motor cortex.

Nature communications

Lu J, Li Y, Zhao Z, Liu Y, Zhu Y, Mao Y, Wu J, Chang EF

Encoding of melody in the human auditory cortex.

bioRxiv : the preprint server for biology

Sankaran N, Leonard MK, Theunissen F, Chang EF

Recommendations for promoting user agency in the design of speech neuroprostheses.

Frontiers in human neuroscience

Sankaran N, Moses D, Chiong W, Chang EF

Interictal epileptiform discharges contribute to word-finding difficulty in epilepsy through multiple cognitive mechanisms.

Epilepsia

Silva AB, Leonard MK, Oganian Y, D'Esopo E, Krish D, Kopald B, Tran EB, Chang EF, Kleen JK

Ictal EEG Source Imaging With Supplemental Electrodes.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

Loube DK, Tan YL, Yoshii-Contreras J, Kleen J, Rao VR, Chang EF, Knowlton RC

A Transcriptomic Comparative Study of Cranial Vasculature.

Translational stroke research

Zhang J, Ryu JY, Tirado SR, Dickinson LD, Abosch A, Aziz-Sultan MA, Boulos AS, Barrow DL, Batjer HH, Binyamin TR, Blackburn SL, Chang EF, Chen PR, Colby GP, Cosgrove GR, David CA, Day AL, Folkerth RD, Frerichs KU, Howard BM, Jahromi BR, Niemela M, Ojemann SG, Patel NJ, Richardson RM, Shi X, Valle-Giler EP, Wang AC, Welch BG, Williams Z, Zusman EE, Weiss ST, Du R, GENIE Investigators

A high-performance neuroprosthesis for speech decoding and avatar control.

Nature

Metzger SL, Littlejohn KT, Silva AB, Moses DA, Seaton MP, Wang R, Dougherty ME, Liu JR, Wu P, Berger MA, Zhuravleva I, Tu-Chan A, Ganguly K, Anumanchipalli GK, Chang EF

Flexible regulation of representations on a drifting manifold enables long-term stable complex neuroprosthetic control.

bioRxiv : the preprint server for biology

Natraj N, Seko S, Abiri R, Yan H, Graham Y, Tu-Chan A, Chang EF, Ganguly K

Association of CDKN2A alterations with increased postoperative seizure risk after resection of brain metastases.

Neurosurgical focus

Cummins DD, Garcia JH, Nguyen MP, Saggi S, Chung JE, Goldschmidt E, Berger MS, Theodosopoulos PV, Chang EF, Daras M, Hervey-Jumper SL, Aghi MK, Morshed RA

Genomic alterations associated with postoperative nodular leptomeningeal disease after resection of brain metastases.

Journal of neurosurgery

Morshed RA, Cummins DD, Nguyen MP, Saggi S, Vasudevan HN, Braunstein SE, Goldschmidt E, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Daras M, Hervey-Jumper SL, Aghi MK

Awake Craniotomy and Electrocorticography-Guided Extended Lesionectomy of Motor Cortex Cavernoma: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)

Raygor KP, Rinaldo L, Dubnicoff TB, Shih T, Chang EF, Abla AA

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.

Journal of visualized experiments : JoVE

Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD

Latent neural dynamics encode temporal context in speech.

Hearing research

Stephen EP, Li Y, Metzger S, Oganian Y, Chang EF

Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.

Brain Stimulation

Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD

Closed-loop neurostimulation for the treatment of psychiatric disorders.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, Krystal AD

Mismatched opioid prescription in patients discharged after neurological surgeries: a retrospective cohort study.

Pain

Campbell LJ, Mummaneni PV, Letchuman V, Langnas E, Agarwal N, Guan LS, Croci R, Vargas E, Reisner L, Bickler P, Chou D, Chang E, Guan Z

First-in-human prediction of chronic pain state using intracranial neural biomarkers.

Nature neuroscience

Shirvalkar P, Prosky J, Chin G, Ahmadipour P, Sani OG, Desai M, Schmitgen A, Dawes H, Shanechi MM, Starr PA, Chang EF

Future directions in psychiatric neurosurgery: Proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical neuromodulation for psychiatric disorders.

Brain Stimulation

Hitti FL, Widge AS, Riva-Posse P, Malone DA, Okun MS, Shanechi MM, Foote KD, Lisanby SH, Ankudowich E, Chivukula S, Chang EF, Gunduz A, Hamani C, Feinsinger A, Kubu CS, Chiong W, Chandler JA, Carbunaru R, Cheeran B, Raike RS, Davis RA, Halpern CH, Vanegas-Arroyave N, Markovic D, Bick SK, McIntyre CC, Richardson RM, Dougherty DD, Kopell BH, Sweet JA, Goodman WK, Sheth SA, Pouratian N

Anatomical registration of intracranial electrodes. Robust model-based localization and deformable smooth brain-shift compensation methods.

bioRxiv : the preprint server for biology

Blenkmann AO, Leske SL, Llorens A, Lin JJ, Chang E, Brunner P, Schalk G, Ivanovic J, Larsson PG, Knight RT, Endestad T, Solbakk AK

Grasp-specific high-frequency broadband mirror neuron activity during reach-and-grasp movements in humans.

Cerebral cortex (New York, N.Y. : 1991)

Dreyer AM, Michalke L, Perry A, Chang EF, Lin JJ, Knight RT, Rieger JW

Glioblastoma remodelling of human neural circuits decreases survival.

Nature

Krishna S, Choudhury A, Keough MB, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Nava Gonzales C, Sudharshan R, Egladyous A, Almeida N, Zhang Y, Molinaro AM, Venkatesh HS, Daniel AGS, Shamardani K, Hyer J, Chang EF, Findlay A, Phillips JJ, Nagarajan S, Raleigh DR, Brang D, Monje M, Hervey-Jumper SL

Phase alignment of low-frequency neural activity to the amplitude envelope of speech reflects evoked responses to acoustic edges, not oscillatory entrainment.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Oganian Y, Kojima K, Breska A, Cai C, Findlay A, Chang E, Nagarajan S

Vowel and formant representation in the human auditory speech cortex.

Neuron

Oganian Y, Bhaya-Grossman I, Johnson K, Chang EF

Apraxia of speech with phonological alexia and agraphia following resection of the left middle precentral gyrus: illustrative case.

Journal of neurosurgery. Case lessons

Levy DF, Silva AB, Scott TL, Liu JR, Harper S, Zhao L, Hullett PW, Kurteff G, Wilson SM, Leonard MK, Chang EF

Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.

Brain Stimulation

Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD

Changes in intracranial neurophysiology associated with acute COVID-19 infection.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD

CDKN2A/B co-deletion is associated with increased risk of local and distant intracranial recurrence after surgical resection of brain metastases.

Neuro-oncology advances

Morshed RA, Nguyen MP, Cummins DD, Saggi S, Young JS, Haddad AF, Goldschmidt E, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Daras M, Aghi MK

Identification of risk factors associated with leptomeningeal disease after resection of brain metastases.

Journal of neurosurgery

Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M

Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Hervey-Jumper SL, Zhang Y, Phillips JJ, Morshed RA, Young JS, McCoy L, Lafontaine M, Luks T, Ammanuel S, Kakaizada S, Egladyous A, Gogos A, Villanueva-Meyer J, Shai A, Warrier G, Rice T, Crane J, Wrensch M, Wiencke JK, Daras M, Oberheim Bush NA, Taylor JW, Butowski N, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Jakola AS, Kavouridis VK, Nawabi N, Solheim O, Smith T, Berger MS, Molinaro AM

On-Call Junior Neurosurgery Residents Spend 9 hours of Their On-Call Shift Actively Using the Electronic Health Record.

Neurosurgery

Patel A, Mummaneni PV, Zheng J, Rosner BI, Thombley R, Sorour O, Theodosopoulos PV, Aghi MK, Berger MS, Chang EF, Chou D, Manley GT, DiGiorgio AM

Intact speech perception after resection of dominant hemisphere primary auditory cortex for the treatment of medically refractory epilepsy: illustrative case.

Journal of neurosurgery. Case lessons

Hullett PW, Kandahari N, Shih TT, Kleen JK, Knowlton RC, Rao VR, Chang EF

Somatic Variants in SVIL in Cerebral Aneurysms.

Neurology. Genetics

Lai PMR, Ryu JY, Park SC, Gross BA, Dickinson LD, Dagen S, Aziz-Sultan MA, Boulos AS, Barrow DL, Batjer HH, Blackburn S, Chang EF, Chen PR, Colby GP, Cosgrove GR, David CA, Day AL, Frerichs KU, Niemela M, Ojemann SG, Patel NJ, Shi X, Valle-Giler EP, Wang AC, Welch BG, Zusman EE, Weiss ST, Du R

A Neurosurgical Functional Dissection of the Middle Precentral Gyrus during Speech Production.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Silva AB, Liu JR, Zhao L, Levy DF, Scott TL, Chang EF

Generalizable spelling using a speech neuroprosthesis in an individual with severe limb and vocal paralysis.

Nature communications

Metzger SL, Liu JR, Moses DA, Dougherty ME, Seaton MP, Littlejohn KT, Chartier J, Anumanchipalli GK, Tu-Chan A, Ganguly K, Chang EF

Evaluating syntactic comprehension during awake intraoperative cortical stimulation mapping.

Journal of neurosurgery

Riva M, Wilson SM, Cai R, Castellano A, Jordan KM, Henry RG, Gorno Tempini ML, Berger MS, Chang EF

Prospective genomically-guided identification of 'early/evolving' and 'undersampled' IDH-wildtype glioblastoma leads to improved clinical outcomes.

Neuro-oncology

Zhang Y, Lucas CG, Young JS, Morshed RA, McCoy L, Oberheim Bush NA, Taylor JW, Daras M, Butowski NA, Villanueva-Meyer JE, Cha S, Wrensch M, Wiencke JK, Lee JC, Pekmezci M, Phillips JJ, Perry A, Bollen AW, Aghi MK, Theodosopoulos P, Chang EF, Hervey-Jumper SL, Berger MS, Clarke JL, Chang SM, Molinaro AM, Solomon DA

Impact of the COVID-19 Pandemic on Neurosurgical Transfers: A Single Tertiary Center Study.

World neurosurgery

Reihl SJ, Garcia JH, Morshed RA, Sankaran S, DiGiorgio A, Chou D, Theodosopoulos PV, Aghi MK, Berger MS, Chang EF, Mummaneni PV

Dissociation of Broca's area from Broca's aphasia in patients undergoing neurosurgical resections.

Journal of neurosurgery

Andrews JP, Cahn N, Speidel BA, Chung JE, Levy DF, Wilson SM, Berger MS, Chang EF

High-density single-unit human cortical recordings using the Neuropixels probe.

Neuron

Chung JE, Sellers KK, Leonard MK, Gwilliams L, Xu D, Dougherty ME, Kharazia V, Metzger SL, Welkenhuysen M, Dutta B, Chang EF

Factors associated with preoperative and postoperative seizures in patients undergoing resection of brain metastases.

Journal of neurosurgery

Garcia JH, Morshed RA, Chung J, Millares Chavez MA, Sudhakar V, Saggi S, Avalos LN, Gallagher A, Young JS, Daras M, McDermott MW, Garcia PA, Chang EF, Aghi MK

Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy.

Brain communications

Fan JM, Lee AT, Kudo K, Ranasinghe KG, Morise H, Findlay AM, Kirsch HE, Chang EF, Nagarajan SS, Rao VR

Harnessing the Power of Artificial Intelligence in Otolaryngology and the Communication Sciences.

Journal of the Association for Research in Otolaryngology : JARO

Wilson BS, Tucci DL, Moses DA, Chang EF, Young NM, Zeng FG, Lesica NA, Bur AM, Kavookjian H, Mussatto C, Penn J, Goodwin S, Kraft S, Wang G, Cohen JM, Ginsburg GS, Dawson G, Francis HW

Decoding naturalistic affective behaviour from spectro-spatial features in multiday human iEEG.

Nature human behaviour

Bijanzadeh M, Khambhati AN, Desai M, Wallace DL, Shafi A, Dawes HE, Sturm VE, Chang EF

A single-cell atlas of the normal and malformed human brain vasculature.

Science (New York, N.Y.)

Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, Lawton MT, Gupta N, Zlokovic BV, Chang EF, Abla AA, Lim DA, Nowakowski TJ

Left hemisphere dominance for bilateral kinematic encoding in the human brain.

eLife

Merrick CM, Dixon TC, Breska A, Lin J, Chang EF, King-Stephens D, Laxer KD, Weber PB, Carmena J, Thomas Knight R, Ivry RB

Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans.

Neuron

Feinsinger A, Pouratian N, Ebadi H, Adolphs R, Andersen R, Beauchamp MS, Chang EF, Crone NE, Collinger JL, Fried I, Mamelak A, Richardson M, Rutishauser U, Sheth SA, Suthana N, Tandon N, Yoshor D, NIH Research Opportunities in Humans Consortium

Postsurgical seizure outcome in temporal lobe epilepsy patients with normal or subtle, nonspecific MRI findings.

Journal of neurosurgery

González Otárula KA, Tan YL, Hall JA, Chang EF, Correa JA, Dubeau F, Sziklas V, Soucy JP, Guiot MC, Knowlton RC, Kobayashi E

Practical Closed-Loop Strategies for Deep Brain Stimulation: Lessons From Chronic Pain.

Frontiers in neuroscience

Prosky J, Cagle J, Sellers KK, Gilron R, de Hemptinne C, Schmitgen A, Starr PA, Chang EF, Shirvalkar P

Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation.

Scientific reports

Schuerman WL, Nourski KV, Rhone AE, Howard MA, Chang EF, Leonard MK

Functional alterations in cortical processing of speech in glioma-infiltrated cortex.

Proceedings of the National Academy of Sciences of the United States of America

Aabedi AA, Lipkin B, Kaur J, Kakaizada S, Valdivia C, Reihl S, Young JS, Lee AT, Krishna S, Berger MS, Chang EF, Brang D, Hervey-Jumper SL

Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology.

Frontiers in human neuroscience

Scangos KW, Khambhati AN, Daly PM, Owen LW, Manning JR, Ambrose JB, Austin E, Dawes HE, Krystal AD, Chang EF

Prefrontal Physiomarkers of Anxiety and Depression in Parkinson's Disease.

Frontiers in neuroscience

de Hemptinne C, Chen W, Racine CA, Seritan AL, Miller AM, Yaroshinsky MS, Wang SS, Gilron R, Little S, Bledsoe I, San Luciano M, Katz M, Chang EF, Dawes HE, Ostrem JL, Starr PA

Speech Computations of the Human Superior Temporal Gyrus.

Annual review of psychology

Bhaya-Grossman I, Chang EF

Decoding Speech from Cortical Surface Electrical Activity. Reply.

The New England journal of medicine

Moses DA, Liu PM, Chang EF

Facial pain and sensory outcomes following resection of tumors compressing the trigeminal nerve.

Journal of neurosurgery

Castro MRH, Magill ST, Morshed RA, Young JS, Braunstein SE, McDermott MW, Chang EF

Closed-loop neuromodulation in an individual with treatment-resistant depression.

Nature medicine

Scangos KW, Khambhati AN, Daly PM, Makhoul GS, Sugrue LP, Zamanian H, Liu TX, Rao VR, Sellers KK, Dawes HE, Starr PA, Krystal AD, Chang EF

Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.

Frontiers in human neuroscience

Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Hu W, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS

Understanding Variable Motor Responses to Direct Electrical Stimulation of the Human Motor Cortex During Brain Surgery.

Frontiers in surgery

Aaronson DM, Martinez Del Campo E, Boerger TF, Conway B, Cornell S, Tate M, Mueller WM, Chang EF, Krucoff MO

Learning nonnative speech sounds changes local encoding in the adult human cortex.

Proceedings of the National Academy of Sciences of the United States of America

Yi HG, Chandrasekaran B, Nourski KV, Rhone AE, Schuerman WL, Howard MA, Chang EF, Leonard MK

Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy.

Science translational medicine

Khambhati AN, Shafi A, Rao VR, Chang EF

Thin-film microfabrication and intraoperative testing of µECoG and iEEG depth arrays for sense and stimulation.

Journal of neural engineering

Sellers KK, Chung JE, Zhou J, Triplett MG, Dawes HE, Haque RU, Chang EF

Correlation of natural language assessment results with health-related quality of life in adult glioma patients.

Journal of neurosurgery

Ammanuel SG, Almeida NC, Kurteff G, Kakaizada S, Molinaro AM, Berger MS, Chang EF, Hervey-Jumper SL

Patient specific prediction of temporal lobe epilepsy surgical outcomes.

Epilepsia

Benjumeda M, Tan YL, González Otárula KA, Chandramohan D, Chang EF, Hall JA, Bielza C, Larrañaga P, Kobayashi E, Knowlton RC

Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria.

The New England journal of medicine

Moses DA, Metzger SL, Liu JR, Anumanchipalli GK, Makin JG, Sun PF, Chartier J, Dougherty ME, Liu PM, Abrams GM, Tu-Chan A, Ganguly K, Chang EF

Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System.

Frontiers in human neuroscience

Sellers KK, Gilron R, Anso J, Louie KH, Shirvalkar PR, Chang EF, Little SJ, Starr PA

Bidirectional propagation of low frequency oscillations over the human hippocampal surface.

Nature communications

Kleen JK, Chung JE, Sellers KK, Zhou J, Triplett M, Lee K, Tooker A, Haque R, Chang EF

Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts.

Frontiers in neurology

Schmitgen A, Saal J, Sankaran N, Desai M, Joseph I, Starr P, Chang EF, Shirvalkar P

Are preoperative chlorhexidine gluconate showers associated with a reduction in surgical site infection following craniotomy? A retrospective cohort analysis of 3126 surgical procedures.

Journal of neurosurgery

Ammanuel SG, Edwards CS, Chan AK, Mummaneni PV, Kidane J, Vargas E, D'Souza S, Nichols AD, Sankaran S, Abla AA, Aghi MK, Chang EF, Hervey-Jumper SL, Kunwar S, Larson PS, Lawton MT, Starr PA, Theodosopoulos PV, Berger MS, McDermott MW

Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.

Frontiers in human neuroscience

Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS

HDMF: Hierarchical Data Modeling Framework for Modern Science Data Standards.

Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data

Tritt AJ, Rübel O, Dichter B, Ly R, Kang D, Chang EF, Frank LM, Bouchard K

Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy.

Cancer discovery

Johanns TM, Miller CA, Dorward IG, Tsien C, Chang E, Perry A, Uppaluri R, Ferguson C, Schmidt RE, Dahiya S, Ansstas G, Mardis ER, Dunn GP

ECoG data analyses to inform closed-loop BCI experiments for speech-based prosthetic applications.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Pailla T, Jiang W, Dichter B, Chang EF, Gilja V