Prasad Shirvalkar, MD, PhD

Assoc Professor in Residence
Assistant Professor Department of Anesthesiology (Pain Management) Department of Neurology UCSF School of Medicine
+1 415 885-7246

Dr. Prasad Shirvalkar is the Principal Investigator of UCSF Clinical Trials for refractory chronic pain (NCT03029884 and NCT04144972) and a neurologist and interventional pain medicine specialist at the UCSF Pain Management Center at Mount Zion. He provides the full spectrum of care for chronic pain conditions, including conservative, nonsurgical treatments such as medications and nerve blocks (anesthetic injections near nerves that are sending pain signals). He also treats patients with advanced neuromodulation therapy by implanting peripheral and spinal cord stimulators, which are devices that relieve pain by sending electrical signals to the spine.

Shirvalkar cares for hospitalized patients and provides telemedicine visits for established patients. He coordinates with other providers for each patient, collaborating to treat any pain condition.

Shirvalkar's research aims to develop new therapies for hard-to-treat pain disorders, such as post-stroke pain and phantom limb pain, by harnessing technologies such as brain and spinal cord stimulation. He is conducting a study using electrodes implanted in the brain to understand how individuals interpret pain signals, with the goal of personalizing brain stimulation therapies. He is also interested in how sudden, severe pain episodes can progress to become chronic and in whether early intervention can prevent chronic pain.

Shirvalkar earned his doctoral and medical degrees at Icahn School of Medicine at Mount Sinai. He then completed a residency in neurology at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center, where he served as chief resident. He completed a fellowship in pain management at UCSF.

Shirvalkar belongs to the American Academy of Neurology, American Pain Association, American Pain Society, American Society of Anesthesiologists, International Neuromodulation Society and North American Neuromodulation Society, where he serves on the scientific program committee.

In addition to medicine and science, Shirvalkar has a passion for percussion. He plays jazz drums in his free time and used to play with the Oakland Raiders' band.

Publications: 

Human Cervical Epidural Spinal Electrogram Topographically Maps Distinct Volitional Movements.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Shukla PD, Burke JF, Kunwar N, Presbrey K, Balakid J, Yaroshinsky M, Louie K, Jacques L, Shirvalkar P, Wang DD

Ambulatory Brain Biomarkers of Chronic Pain: Towards Closed Loop Brain Stimulation.

Biological Psychiatry

Prasad Shirvalkar, Philip A. Starr, Edward F. Chang

Editorial: Advancements in deep brain stimulation for chronic pain control.

Frontiers in pain research (Lausanne, Switzerland)

Staudt MD, Yaghi NK, Mazur-Hart DJ, Shirvalkar P

Quantifying Pain Location and Intensity with Multimodal Pain Body Diagrams.

Journal of visualized experiments : JoVE

Kwong J, Lin J, Leriche R, Wozny TA, Shaughnessy A, Schmitgen A, Shirvalkar P

Network targets for therapeutic brain stimulation: towards personalized therapy for pain.

Frontiers in pain research (Lausanne, Switzerland)

Motzkin JC, Kanungo I, D'Esposito M, Shirvalkar P

ID: 221565 EEG Signatures of Epidural Spinal Cord Stimulation: A Dosing and Mechanism of Action Study.

Neuromodulation Technology at the Neural Interface

Chad Sitgraves, Prasad Shirvalkar, Lawrence Poree

First-in-human prediction of chronic pain state using intracranial neural biomarkers.

Nature neuroscience

Shirvalkar P, Prosky J, Chin G, Ahmadipour P, Sani OG, Desai M, Schmitgen A, Dawes H, Shanechi MM, Starr PA, Chang EF

Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury.

Frontiers in human neuroscience

Wong JK, Deuschl G, Wolke R, Bergman H, Muthuraman M, Groppa S, Sheth SA, Bronte-Stewart HM, Wilkins KB, Petrucci MN, Lambert E, Kehnemouyi Y, Starr PA, Little S, Anso J, Gilron R, Poree L, Kalamangalam GP, Worrell GA, Miller KJ, Schiff ND, Butson CR, Henderson JM, Judy JW, Ramirez-Zamora A, Foote KD, Silburn PA, Li L, Oyama G, Kamo H, Sekimoto S, Hattori N, Giordano JJ, DiEuliis D, Shook JR, Doughtery DD, Widge AS, Mayberg HS, Cha J, Choi K, Heisig S, Obatusin M, Opri E, Kaufman SB, Shirvalkar P, Rozell CJ, Alagapan S, Raike RS, Bokil H, Green D, Okun MS

Practical Closed-Loop Strategies for Deep Brain Stimulation: Lessons From Chronic Pain.

Frontiers in neuroscience

Prosky J, Cagle J, Sellers KK, Gilron R, de Hemptinne C, Schmitgen A, Starr PA, Chang EF, Shirvalkar P

Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants.

Frontiers in human neuroscience

Burke JF, Kunwar N, Yaroshinsky MS, Louie KH, Shirvalkar P, Su P, Henry M, Pasvankas G, Poree L, Jacques L, Wang DD

Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.

Frontiers in human neuroscience

Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Hu W, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS

High-Frequency Impulse Therapy for Treatment of Chronic Back Pain: A Multicenter Randomized Controlled Pilot Study.

Journal of pain research

Amirdelfan K, Hong M, Tay B, Reddy S, Reddy V, Yang M, Khanna K, Shirvalkar P, Abrecht C, Gulati A

Analysis-rcs-data: Open-Source Toolbox for the Ingestion, Time-Alignment, and Visualization of Sense and Stimulation Data From the Medtronic Summit RC+S System.

Frontiers in human neuroscience

Sellers KK, Gilron R, Anso J, Louie KH, Shirvalkar PR, Chang EF, Little SJ, Starr PA

Emerging Therapies for the Treatment of Complex Regional Pain Syndrome.

Po-Yi Paul Su, Shikha Sharma, Prasad Shirvalkar, Lawrence Poree

Musical Hallucinations in Chronic Pain: The Anterior Cingulate Cortex Regulates Internally Generated Percepts.

Frontiers in neurology

Schmitgen A, Saal J, Sankaran N, Desai M, Joseph I, Starr P, Chang EF, Shirvalkar P

Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.

Frontiers in human neuroscience

Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS

Decoding Acute and Chronic Pain State from Ambulatory Intracranial Recordings: Towards Closed-Loop Brain Stimulation (233).

Neurology

Prasad Shirvalkar, Gregory Chin, Heather Dawes, Philip Starr, Edward Chang

Amyloid-Beta Related Angitiis and Reversible Cerebral Vasoconstriction Syndrome: A Case Report (P6.057).

Neurology

Thomas Tropea, Prasad Shirvalkar, Krithiga Sekar, Kyung-Wha Kim, Apostolos Tsiouris, Ehud Lavi, Alan Segal

Conference Curriculum Content and Organization in United States Neurology Residencies: A Cross-Sectional Survey (P2.354).

Neurology

Arthie Jeyakumar, Pravin Khemani, Ralph Jozefowicz, Prasad Shirvalkar, Augusto Miravalle, Constantine Farmakidis

Widespread Leptomeningeal Involvement in Borreliosis (P2.317).

Neurology

Carolina Maciel, Erwin Wang, Prasad Shirvalkar, Alexander Merkler, Joseph Safdieh